Furo[3,2-b]pyridin-3(2H)-one(9CI)

Base Information

• Chemical Name: Furo[3,2-b]pyridin-3(2H)-one(9CI)
• CAS No.: 119293-03-7
• Molecular Formula: C7H5NO2
• Molecular Weight: 135.122
• Mol file: 119293-03-7.mol

Synonyms:Furo[3,2-b]pyridin-3(2H)-one(9CI);furo[3,2-b]pyridin-3-ol;furo[3,2-b]pyridin-3(2H)-one;Furo[3,2-b]pyridin-3-one

Chemical Property of Furo[3,2-b]pyridin-3(2H)-one(9CI)

Chemical Property:

• Boiling Point: 289.63 °C at 760 mmHg
• PKA: 2.47±0.20(Predicted)
• Flash Point: 128.964 °C
• PSA: 39.19000
• Density: 1.361 g/cm³
• LogP: 0.65670
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Furo[3,2-b]pyridin-3(2H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furo[3,2-b]pyridin-3(2H)-one(9CI)

There total 6 articles about Furo[3,2-b]pyridin-3(2H)-one(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-ethoxyfuro<3,2-b>pyridine (119292-94-3) → furo<3,2-b>pyridin-3(2H)-one (119293-03-7)

Guidance literature:

With diclazuril; water-d2; at 70 ℃; for 72h;

Reference yield:

furo[3,2-b]pyridin-3(2H)-one hydrochloride (107096-00-4) → furo<3,2-b>pyridin-3(2H)-one (119293-03-7)

Guidance literature:

With sodium hydrogencarbonate; In water;

Reference yield:

ethyl 3-hydroxyfuro<3,2-b>pyridine-2-carboxylate (107095-99-8) → furo<3,2-b>pyridin-3(2H)-one (119293-03-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / K₂CO₃ / acetone / 5 h / Heating

2: 72 percent / NaOEt / toluene; ethanol / 2 h / Heating

3: KOH / H₂O; ethanol / 1 h / Heating

4: Cu powder / pyrolized

5: 95 percent / 15percent DCl/D₂O / 72 h / 70 °C

With potassium hydroxide; diclazuril; water-d2; sodium ethanolate; copper; potassium carbonate; In ethanol; water; acetone; toluene;

upstream raw materials:

3-ethoxyfuro<3,2-b>pyridine

ethyl 3-hydroxyfuro<3,2-b>pyridine-2-carboxylate

ethyl 3-ethoxyfuro<3,2-b>pyridine-2-carboxylate

ethyl 3-ethoxycarbonylmethoxyfuro<3,2-b>pyridine-2-carboxylate

Refernces

• 1、 Shiotani, Shunsaku,Morita, Hiroyuki,Ishida, Toshimasa,In, Yasuko. "Furopyridines. IX . Syntheses and Properties of 3-Ethoxy Derivatives of Furo-, Furo-, Furo- and Furopyridine". . p. 1205 - 1213. Retrieved 2007/10/02.