1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester
• CAS No.: 183268-77-1
• Molecular Formula: C₁₅H₁₆N₂O₄
• Molecular Weight: 288.303
• Mol file: 183268-77-1.mol

Synonyms:1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester

Chemical Property of 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester

There total 5 articles about 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

ethyl 1-benzyl-5-methyl-1H-pyrrole-2-carboxylate (183268-74-8) → 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester (183268-77-1)

Guidance literature:

With nitric acid;

DOI:10.1039/P19960002277

Reference yield:

2-methyl-1H-pyrrole (636-41-9) → 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester (183268-77-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / diethyl ether / 1 h

2: 76 percent / NaOEt / 0.5 h / Ambient temperature

3: 89 percent / KOH / dimethylsulfoxide

4: 22 percent / 70percent HNO₃

With potassium hydroxide; nitric acid; sodium ethanolate; In diethyl ether; dimethyl sulfoxide;

DOI:10.1039/P19960002277

Reference yield:

ethyl 5-methyl-1H-pyrrole-2-carboxylate (3284-51-3) → 1-Benzyl-5-methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester (183268-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / KOH / dimethylsulfoxide

2: 22 percent / 70percent HNO₃

With potassium hydroxide; nitric acid; In dimethyl sulfoxide;

DOI:10.1039/P19960002277

upstream raw materials:

ethyl 1-benzyl-5-methyl-1H-pyrrole-2-carboxylate

2-methyl-1H-pyrrole

ethyl 5-methyl-1H-pyrrole-2-carboxylate

Ethyl 5-methyl-4-nitropyrrole-2-carboxylate

Downstream raw materials:

1-Benzyl-5-methyl-4-nitropyrrole-2-carboxylic acid