Technology Process of 6-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole
There total 10 articles about 6-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-ol;
With
methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
With
sodium azide;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / methanol / 24 h / Reflux
1.2: 1 h / 70 °C
1.3: 2 h / 50 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; water / 0.5 h / 20 °C
3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere
3.2: 0.5 h / 60 °C
4.1: hydrogenchloride / methanol; tetrahydrofuran / 1 h / 70 °C
4.2: 0.33 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere
6.1: tetrahydrofuran
6.2: 0.17 h / 20 °C / Enzymatic reaction
7.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 20 °C
7.2: 2 h / 100 °C
With
hydrogenchloride; oxalyl dichloride; sulfuric acid; potassium tert-butylate; sulfur trioxide pyridine complex; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; water / 0.5 h / 20 °C
2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere
2.2: 0.5 h / 60 °C
3.1: hydrogenchloride / methanol; tetrahydrofuran / 1 h / 70 °C
3.2: 0.33 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere
5.1: tetrahydrofuran
5.2: 0.17 h / 20 °C / Enzymatic reaction
6.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 20 °C
6.2: 2 h / 100 °C
With
hydrogenchloride; oxalyl dichloride; potassium tert-butylate; sulfur trioxide pyridine complex; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
