(S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

Base Information

Chemical Name:(S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid
CAS No.:1392841-85-8
Molecular Formula:C₂₀H₁₆N₄O₅
Molecular Weight:392.371
Hs Code.:

Synonyms:(S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

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Chemical Property of (S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

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Technology Process of (S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

There total 6 articles about (S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56-41-7,25191-17-7,18875-37-1
L-alanin

: 1392839-24-5
7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 1392841-85-8
(S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

Guidance literature:: With sodium methylate; In methanol; for 48h; Reflux;

Reference yield:

: 33707-25-4
1-benzyl-2-oxo-1,2-dihydro-pyridine-3,4-dicarboxylic acid 4-ethyl ester 3-methyl ester

: 1392841-85-8
(S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine; lithium iodide / 1 h / Reflux

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

2.2: 16 h / 20 °C

2.3: 16 h / 20 °C

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium methylate / methanol

4.2: pH 4

5.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

6.1: N,N-dimethyl-formamide / 0.13 h / Reflux; Inert atmosphere

7.1: sodium methylate / methanol / 48 h / Reflux

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1392839-20-1
1-benzyl-3-bromomethyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid ethyl ester

: 1392841-85-8
(S)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium methylate / methanol

2.2: pH 4

3.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

4.1: N,N-dimethyl-formamide / 0.13 h / Reflux; Inert atmosphere

5.1: sodium methylate / methanol / 48 h / Reflux

With sodium methylate; potassium carbonate; sodium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;