4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

Base Information

Chemical Name:4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol
CAS No.:192771-98-5
Molecular Formula:C₃₅H₃₈N₂O₂
Molecular Weight:518.699
Hs Code.:

4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1<i>H</i>-indol-3-yl]-ethylamino}-butyl)-phenol

Synonyms:4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

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Chemical Property of 4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

Chemical Property:

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Technology Process of 4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

There total 7 articles about 4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethyl}-4-(4-hydroxy-phenyl)-butyramide

: 192771-98-5
4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

Guidance literature:: N-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethyl}-4-(4-hydroxy-phenyl)-butyramide; With borane-THF; In tetrahydrofuran; for 3h; Heating;

With 2-(N,N-dimethylamino)ethanol; In tetrahydrofuran; methanol; for 3h; Heating;
DOI:10.1016/S0960-894X(00)00708-3

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 192771-98-5
4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBT; EDAC / dimethylformamide; CH₂Cl₂

2.1: BH₃*THF / tetrahydrofuran / 3 h / Heating

2.2: N,N-dimethylethanolamine / methanol; tetrahydrofuran / 3 h / Heating

With borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00708-3

Reference yield:

: 20776-45-8
5-benzyloxytryptamine

: 192771-98-5
4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / Heating

2.1: pyridine hydrobromide perbromide / tetrahydrofuran; CHCl₃

3.1: Na₂CO₃; LiCl; Pd(PPh₃)4 / toluene; ethanol / 1.25 h / Heating

4.1: aq. hydrazine / tetrahydrofuran; ethanol

5.1: HOBT; EDAC / dimethylformamide; CH₂Cl₂

6.1: BH₃*THF / tetrahydrofuran / 3 h / Heating

6.2: N,N-dimethylethanolamine / methanol; tetrahydrofuran / 3 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; pyridinium hydrobromide perbromide; sodium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 3.1: modified Suzuki reaction;
DOI:10.1016/S0960-894X(00)00708-3