Technology Process of (5R)-<(2R)-benzyloxypropyl>tetrahydro-2-furanthione
There total 7 articles about (5R)-<(2R)-benzyloxypropyl>tetrahydro-2-furanthione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: TiCl4 / CH2Cl2 / -78 °C
2: 98 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 18 h / Ambient temperature
3: 1) BH3, 2) 30percent H2O2, 3 M NaOH / 1) THF, r.t., 1 h, 2) r.t., 1 h
4: 90 percent / (COCl)2, DMSO / CH2Cl2 / 0.83 h / -50 °C
5: 90 percent / 2-methyl-2-butene, NaCl, KH2PO4, H2O / 2-methyl-propan-2-ol / 3 h / Ambient temperature
6: 100 percent / 10percent HCl / tetrahydrofuran / 3 h / Ambient temperature
7: 83 percent / toluene / 0.5 h / Heating; Lawesson's reagent
With
hydrogenchloride; sodium hydroxide; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; borane; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; titanium tetrachloride; dimethyl sulfoxide; sodium chloride;
In
tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)80580-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 18 h / Ambient temperature
2: 1) BH3, 2) 30percent H2O2, 3 M NaOH / 1) THF, r.t., 1 h, 2) r.t., 1 h
3: 90 percent / (COCl)2, DMSO / CH2Cl2 / 0.83 h / -50 °C
4: 90 percent / 2-methyl-2-butene, NaCl, KH2PO4, H2O / 2-methyl-propan-2-ol / 3 h / Ambient temperature
5: 100 percent / 10percent HCl / tetrahydrofuran / 3 h / Ambient temperature
6: 83 percent / toluene / 0.5 h / Heating; Lawesson's reagent
With
hydrogenchloride; sodium hydroxide; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; borane; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; dimethyl sulfoxide; sodium chloride;
In
tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)80580-9
