(15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

Base Information

Chemical Name:(15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate
CAS No.:1421280-16-1
Molecular Formula:C₂₃H₃₅NO₄
Molecular Weight:389.535
Hs Code.:

Synonyms:(15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

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Chemical Property of (15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

Chemical Property:

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Technology Process of (15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

There total 3 articles about (15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 134627-14-8
(+)-1-Phenyl-hexan-3-ol

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1421280-16-1
(15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm3015052

Reference yield:

: 60340-28-5,98088-55-2,98088-54-1
(R)-1-phenyl-hex-5-en-3-ol

: 1421280-16-1
(15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 2.5 h / 20 °C

2: diisopropyl-carbodiimide; dmap / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With dmap; 5%-palladium/activated carbon; hydrogen; diisopropyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1021/jm3015052

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1421280-16-1
(15S,2S)-1-phenylhexan-3-yl 1-(2-oxo-2-phenylacetyl)piperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane; diethyl ether / -100 - 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere; Reflux

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 2.5 h / 20 °C

3.1: diisopropyl-carbodiimide; dmap / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With dmap; 5%-palladium/activated carbon; hydrogen; diisopropyl-carbodiimide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm3015052