(R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

Base Information

Chemical Name:(R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine
CAS No.:1144501-46-1
Molecular Formula:C₈H₈O₃*C₁₁H₁₅NO
Molecular Weight:329.396
Hs Code.:

Synonyms:(R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

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Chemical Property of (R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

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Technology Process of (R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

There total 5 articles about (R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 611-71-2
(R)-Mandelic Acid

: 235423-04-8
(R)-4-amino-3,4-dihydro-2,2-dimethyl-2H-benzopyran

: 1144501-46-1
(R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

Guidance literature:: In isopropyl alcohol; at 50 ℃; for 0.166667h;

Reference yield:

: 1072930-94-9
4-azido-2,2-dimethyl-3,4-dihydro-2H-chromene

: 611-71-2
(R)-Mandelic Acid

: 1144501-46-1
(R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

Guidance literature:: 4-azido-2,2-dimethyl-3,4-dihydro-2H-chromene; With water; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 2.5h;

(R)-Mandelic Acid; In isopropyl alcohol; at 50 ℃; optical yield given as %de;
DOI:10.1016/j.tetlet.2010.09.006

Reference yield:

: 1072930-94-9
4-azido-2,2-dimethyl-3,4-dihydro-2H-chromene

: 1144501-46-1
(R)-2-hydroxy-2-phenylacetate salt of (R)-2,2-dimethylchroman-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / tetrahydrofuran; water / 3 h / 60 °C

2: isopropyl alcohol / 0.17 h / 50 °C

With triphenylphosphine; In tetrahydrofuran; water; isopropyl alcohol;