2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one

Base Information

• Chemical Name: 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one
• CAS No.: 364802-28-8
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39

Synonyms:2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one

Chemical Property of 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one

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Technology Process of 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one

There total 4 articles about 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-2-[Acryloyl-(2-azido-benzyl)-amino]-propionic acid benzyl ester (364802-17-5) → 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one (364802-28-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 4h; Heating;

DOI:10.1016/j.tetasy.2007.05.015

Reference yield: 53.0%

2-(4-oxo-3a,4-dihydro-3H,6H-1,2,5,10b-tetraaza-benzo[e]azulen-5-yl)-propionic acid benzyl ester (364802-21-1) → 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one (364802-28-8) + 2-(2-oxo-1a,2-dihydro-1H,4H-3,8b-diaza-benzo[a]cyclopropa[c]cyclohepten-3-yl)-propionic acid benzyl ester

Guidance literature:

With triethylamine; In toluene; for 8h; Heating;

DOI:10.1016/S0957-4166(01)00190-2

Reference yield: 48.0%

2-(4-oxo-3a,4-dihydro-3H,6H-1,2,5,10b-tetraaza-benzo[e]azulen-5-yl)-propionic acid benzyl ester (364802-20-0) → 2-methyl-4-[1-(S)-(benzyloxycarbonyl)ethyl]-4,5-dihydro-1,4-benzodiazepin-3-one (364802-28-8) + 2-(2-oxo-1a,2-dihydro-1H,4H-3,8b-diaza-benzo[a]cyclopropa[c]cyclohepten-3-yl)-propionic acid benzyl ester

Guidance literature:

With triethylamine; In toluene; for 1h; Heating;

DOI:10.1016/S0957-4166(01)00190-2

upstream raw materials:

2-(4-oxo-3a,4-dihydro-3H,6H-1,2,5,10b-tetraaza-benzo[e]azulen-5-yl)-propionic acid benzyl ester

2-(4-oxo-3a,4-dihydro-3H,6H-1,2,5,10b-tetraaza-benzo[e]azulen-5-yl)-propionic acid benzyl ester

(S)-2-[Acryloyl-(2-azido-benzyl)-amino]-propionic acid benzyl ester

(S)-2-[Acryloyl-(2-amino-benzyl)-amino]-propionic acid benzyl ester

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