((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: ((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester
• CAS No.: 194597-88-1
• Molecular Formula: C₁₈H₂₀ClNO₄S
• Molecular Weight: 381.88
• Mol file: 194597-88-1.mol

Synonyms:((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester

Chemical Property of ((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester

There total 1 articles about ((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-S-3-(benzyloxycarbonylamino)-4-phenylbutyl ethanethioate → ((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester (194597-88-1)

Guidance literature:

With hydrogenchloride; chlorine; acetic acid; at 0 ℃;

DOI:10.1016/S0960-894X(00)00163-3

Reference yield:

((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester (194597-88-1) → (S)-3-Amino-4-phenyl-butane-1-sulfonyl chloride

Guidance literature:

With hydrogen bromide; In acetic acid;

DOI:10.1016/S0960-894X(00)00163-3

Reference yield:

((S)-1-Benzyl-3-chlorosulfonyl-propyl)-carbamic acid benzyl ester (194597-88-1) → (3S,5S)-3,5-Dibenzyl-isothiazolidine 1,1-dioxide

Guidance literature:

Multi-step reaction with 5 steps

1: HBr / acetic acid

2: TEA / tetrahydrofuran

3: tetrahydrofuran

4: LDA / tetrahydrofuran

5: TFA / CH₂Cl₂

With TEA; hydrogen bromide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetic acid; 1: acidolysis / 2: Cyclization / 3: Acylation / 4: Alkylation / 5: acidolysis;

DOI:10.1016/S0960-894X(00)00163-3

Downstream raw materials:

(3S)-3-benzylisothiazolidine 1,1-dioxide