benidipine

Base Information

• Chemical Name: benidipine
• CAS No.: 119065-61-1
• Molecular Formula: C₂₈H₃₁N₃O₆
• Molecular Weight: 505.571
• Mol file: 119065-61-1.mol

Synonyms:3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl1-(phenylmethyl)-3-piperidinyl ester, [R-(R*,S*)]-; (-)-Benidipine

Chemical Property of benidipine

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benidipine

There total 25 articles about benidipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxypiperazine (6859-99-0) → benidipine (105979-17-7,119065-61-1,119065-60-0,91599-75-6)

Guidance literature:

Multi-step reaction with 3 steps

2: triethylamine / toluene / 5 h / Heating

3: dimethylformamide; CH₂Cl₂ / 2 h

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

(3R)-piperidin-3-ol (62414-68-0) → benidipine (105979-17-7,119065-61-1,119065-60-0,91599-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 5 h / Heating

2: dimethylformamide; CH₂Cl₂ / 2 h

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

(+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid (76093-34-0) → benidipine (105979-17-7,119065-61-1,119065-60-0,91599-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

2: dimethylformamide; CH₂Cl₂ / 2 h

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

(R)-N-benzyl-3-hydroxypiperidine

3-hydroxypiperazine

(3R)-piperidin-3-ol