3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Base Information

Chemical Name:3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one
CAS No.:1473453-11-0
Molecular Formula:C₂₂H₂₁NO₂
Molecular Weight:331.414
Hs Code.:

Synonyms:3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

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Chemical Property of 3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Chemical Property:

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Technology Process of 3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

There total 5 articles about 3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1473453-14-3
1-bromo-3,6-dimethyl-6,7-dihydro-2H-isoindol-4(5H)-one

: 108238-09-1
2-phenoxyphenylboronic acid

: 1473453-11-0
3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 20 - 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 81930-38-3
2-acetyl-5-methyl-1,3-cyclohexanedione

: 1473453-11-0
3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; acetic acid; hydrogenchloride / 18 h / 100 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 72 h / 60 °C

2.2: 0.5 h / 100 °C

3.1: N-Bromosuccinimide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; 1,2-dimethoxyethane; water / 0.5 h / 20 - 120 °C / Microwave irradiation

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium hydroxide monohydrate; water; sodium acetate; sodium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; 4.1: |Suzuki Coupling;

Reference yield:

: 1473453-12-1
ethyl 3,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

: 1473453-11-0
3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 72 h / 60 °C

1.2: 0.5 h / 100 °C

2.1: N-Bromosuccinimide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; 1,2-dimethoxyethane; water / 0.5 h / 20 - 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium hydroxide monohydrate; water; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; 3.1: |Suzuki Coupling;