(S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one

Base Information

• Chemical Name: (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one
• CAS No.: 863225-35-8
• Molecular Formula: C₂₈H₃₈NO₆P
• Molecular Weight: 515.587

Synonyms:(S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one

Chemical Property of (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one

There total 4 articles about (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R/S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one (847672-62-2) → (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one (863225-35-8) + (R)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one (863225-37-0)

Guidance literature:

chiral HPLC;

DOI:10.1021/jm050242f

Reference yield:

(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one (847672-61-1) → (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one (863225-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrazole / CH₂Cl₂; tetrahydrofuran / 18 h / 20 °C

1.2: aq. H₂O₂ / CH₂Cl₂; tetrahydrofuran / 1.5 h / 20 °C

2.1: chiral HPLC

With 1H-tetrazole; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm050242f

Reference yield:

3-(diethylamino)-1,5-dihydro-2,4,3-benzodioxaphosphepin triphenyl phosphite → (S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one (863225-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrazole / CH₂Cl₂; tetrahydrofuran / 18 h / 20 °C

1.2: aq. H₂O₂ / CH₂Cl₂; tetrahydrofuran / 1.5 h / 20 °C

2.1: chiral HPLC

With 1H-tetrazole; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm050242f

upstream raw materials:

(R/S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one

(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one

fingolimod

Downstream raw materials:

(S)-fingolimod phosphate

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