N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester

Base Information

• Chemical Name: N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester
• CAS No.: 86099-39-0
• Molecular Formula: C₅₃H₇₁N₁₁O₁₂
• Molecular Weight: 1054.21

Synonyms:N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester

Chemical Property of N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester

There total 12 articles about N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

Nα-benzyloxycarbonyl-NG-nitroarginylglycine (21466-92-2) + prolylprolylphenylalanylisoleucylvaline benzyl ester → Nα-benzyloxycarbonyl-NG-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester (86099-39-0)

Guidance literature:

With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In chloroform; N,N-dimethyl-formamide; a) 0 deg C, 3 h, b) RT, overnight;

DOI:10.1246/bcsj.56.766

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → Nα-benzyloxycarbonyl-NG-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester (86099-39-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / dicyclohexylcarbodiimide / acetonitrile / 3 h / 0 °C

2: 74 percent / H₂ / Pd / methanol / 48 h / Ambient temperature

3: N-methylmorpholine / tetrahydrofuran; CHCl₃ / 0.17 h / -5 °C

4: tetrahydrofuran; CHCl₃ / Ambient temperature

5: 97 percent / 4 M aq. HCl / dioxane / 1 h / Ambient temperature

6: 69 percent / dicyclohexycarbodiimide, N-methylmorpholine / dimethylformamide; CHCl₃ / a) 0 deg C, 3 h, b) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1246/bcsj.56.766

Reference yield:

N-(tert-butyloxycarbonyl)-prolyl-proline benzyl ester (29776-70-3) → Nα-benzyloxycarbonyl-NG-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester (86099-39-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 74 percent / H₂ / Pd / methanol / 48 h / Ambient temperature

2: N-methylmorpholine / tetrahydrofuran; CHCl₃ / 0.17 h / -5 °C

3: tetrahydrofuran; CHCl₃ / Ambient temperature

4: 97 percent / 4 M aq. HCl / dioxane / 1 h / Ambient temperature

5: 69 percent / dicyclohexycarbodiimide, N-methylmorpholine / dimethylformamide; CHCl₃ / a) 0 deg C, 3 h, b) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.56.766

upstream raw materials:

N^α-benzyloxycarbonyl-N^G-nitroarginylglycine

1-(tert-butoxycarbonyl)-L-proline

N^α-benzyloxycarbonyl-N^G-nitroarginylglycine benzyl ester

N₅-[imino(nitroamino)methyl]-N₂-[(phenylmethoxy)carbonyl]-L-ornithine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 86099-39-0 N^α-benzyloxycarbonyl-N^G-nitroarginylglycylprolylprolylphenylalanylisoleucylvaline benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send