2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

Base Information

Chemical Name:2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin
CAS No.:119841-76-8
Molecular Formula:C₂₀H₁₅ClO₈
Molecular Weight:418.787
Hs Code.:

Synonyms:2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

Chemical Property:

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Technology Process of 2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

There total 3 articles about 2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 119841-82-6
2'-chloro-4',5'-dide-O-methylepipodophyllotoxin

: 119841-76-8
2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

Guidance literature:: With sodium periodate; In methanol; water; for 0.166667h;
DOI:10.1039/P19880002573

Reference yield:

: 1014671-34-1
(-)-podophyllotoxin

: 119841-76-8
2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / conc. nitric acid / propionic acid / 0.07 h / 0 °C

2: 1.) hydrogen chloride 2.) calcium carbonate / 1.) chloroform, 0 deg C, 15 min 2.) acetone-water, 50 deg C, 2 h

3: 80 percent / sodium metaperiodate / methanol; H₂O / 0.17 h

With hydrogenchloride; sodium periodate; nitric acid; calcium carbonate; In methanol; water; propionic acid;
DOI:10.1039/P19880002573

Reference yield:

: 50905-41-4,109010-93-7
3',4'-didemethoxy-3',4'-dihydro-3',4'-dioxoepipodophyllotoxin

: 119841-76-8
2'-chloro-4',5'-didemethoxy-4',5'-dihydro-4',5'-dioxoepipodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) hydrogen chloride 2.) calcium carbonate / 1.) chloroform, 0 deg C, 15 min 2.) acetone-water, 50 deg C, 2 h

2: 80 percent / sodium metaperiodate / methanol; H₂O / 0.17 h

With hydrogenchloride; sodium periodate; calcium carbonate; In methanol; water;
DOI:10.1039/P19880002573