2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine

Base Information

• Chemical Name: 2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine
• CAS No.: 141519-07-5
• Molecular Formula: C₁₃H₂₀N₄O₂
• Molecular Weight: 264.327

Synonyms:2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine

Chemical Property of 2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine

Chemical Property:

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Technology Process of 2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine

There total 2 articles about 2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4-(5-Cyclohexyl-4-nitro-2H-pyrazol-3-ylamino)-butan-1-ol (132026-68-7) → 2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine (141519-07-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00018a012

Reference yield:

3-chloro-5-cyclohexyl-4-nitro-1(2)H-pyrazole (55119-92-1) → 2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine (141519-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / ethanol / 5 h / 100 °C

2: 42 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 2 h / Ambient temperature

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00018a012

Reference yield:

2-cyclohexyl-3-nitro-5,6,7,8-tetrahydro-4H-pyrazolo<2,3-α><1,3>diazepine (141519-07-5) → 2-Cyclohexyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,3]diazepin-3-ylamine (141519-08-6)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; at 50 ℃; for 3h;

DOI:10.1021/jm00018a012

upstream raw materials:

4-(5-Cyclohexyl-4-nitro-2H-pyrazol-3-ylamino)-butan-1-ol

3-chloro-5-cyclohexyl-4-nitro-1⁽²⁾H-pyrazole

Downstream raw materials:

2-Cyclohexyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,3]diazepin-3-ylamine

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