(3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

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Chemical Name:(3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid
CAS No.:1269755-17-0
Molecular Formula:C₂₉H₃₃NO₅Si
Molecular Weight:503.67
Hs Code.:

Synonyms:(3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

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Chemical Property of (3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

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Technology Process of (3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

There total 9 articles about (3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269755-20-5
(3R,4S)-benzyl 3-(tert-butyldiphenylsilyloxy)-4-vinylpyrrolidine-1-carboxylate

: 1269755-17-0
(3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

Guidance literature:: (3R,4S)-benzyl 3-(tert-butyldiphenylsilyloxy)-4-vinylpyrrolidine-1-carboxylate; With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃;

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 20 ℃; for 3h;

Reference yield:

: 31970-04-4
1-carboxybenzyl-3-pyrrolidine

: 1269755-17-0
(3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

1.2: 1 h / 20 °C

2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -40 °C

3.1: CHIRALPAK AD / n-heptane; ethanol; methanol / Resolution of racemate

4.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

5.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 20 °C

5.2: 3 h / 20 °C

With 1H-imidazole; ruthenium trichloride; sodium periodate; copper(I) bromide dimethylsulfide complex; 3-chloro-benzenecarboperoxoic acid; CHIRALPAK AD; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; n-heptane; dichloromethane; water; acetonitrile;

Reference yield:

: 31865-25-5
benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1269755-17-0
(3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -40 °C

2.1: CHIRALPAK AD / n-heptane; ethanol; methanol / Resolution of racemate

3.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

4.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 20 °C

4.2: 3 h / 20 °C

With 1H-imidazole; ruthenium trichloride; sodium periodate; copper(I) bromide dimethylsulfide complex; CHIRALPAK AD; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; n-heptane; dichloromethane; water; acetonitrile;