Technology Process of 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane
There total 8 articles about 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 0 - 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: zinc/copper couple / 48 h / 20 °C / Inert atmosphere
2: zinc; ammonium chloride / methanol; water / 8 h / 20 °C
3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr
4: triethylamine / dichloromethane / 5 h / 20 °C
5: sodium tetrahydroborate / methanol / 6 h / 0 - 20 °C
With
sodium tetrahydroborate; zinc/copper couple; palladium 10% on activated carbon; hydrogen; ammonium chloride; triethylamine; zinc;
In
methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: zinc; ammonium chloride / methanol; water / 8 h / 20 °C
2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr
3: triethylamine / dichloromethane / 5 h / 20 °C
4: sodium tetrahydroborate / methanol / 6 h / 0 - 20 °C
With
sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; ammonium chloride; triethylamine; zinc;
In
methanol; dichloromethane; water;
