5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

Base Information

Chemical Name:5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide
CAS No.:855299-67-1
Molecular Formula:C₃₁H₃₀ClN₃O₄
Molecular Weight:544.05
Hs Code.:

5,6,7-trimethoxy-1<i>H</i>-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

Synonyms:5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

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Chemical Property of 5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

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Technology Process of 5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

There total 10 articles about 5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 855299-70-6
methanesulfonic acid 2-{4-benzylamino-2-[(5,6,7-trimethoxy-1H-indole-2-carbonyl)-amino]-naphthalen-1-yl}-ethyl ester

: 855299-67-1
5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1021/jm050179u

Reference yield:

: 855299-62-6
2-[4-(N-benzylamino)-2-nitronaphthalen-1-yl]ethanol

: 855299-67-1
5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / CCl₄; Ph₃P / CH₂Cl₂ / 3 h

2: H₂ / PtO₂ / tetrahydrofuran / 1 h / 20 °C / 2844.31 Torr

3: 62.0 mg / benzotriazol-1-yloxytripyrolidinophosphonium PF₆; iPr₂NEt / CH₂Cl₂

With tetrachloromethane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050179u

Reference yield:

: 855299-61-5
[4-(N-benzylamino)-2-nitronaphthalen-1-yl]acetic acid

: 855299-67-1
5,6,7-trimethoxy-1H-indole-2-carboxylic acid [4-benzylamino-1-(2-chloro-ethyl)-naphthalen-2-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / BH₃ / tetrahydrofuran

2: 95 percent / CCl₄; Ph₃P / CH₂Cl₂ / 3 h

3: H₂ / PtO₂ / tetrahydrofuran / 1 h / 20 °C / 2844.31 Torr

4: 62.0 mg / benzotriazol-1-yloxytripyrolidinophosphonium PF₆; iPr₂NEt / CH₂Cl₂

With tetrachloromethane; borane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050179u