4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile

Base Information

• Chemical Name: 4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile
• CAS No.: 1352622-24-2
• Molecular Formula: C₁₃H₉ClFN₅
• Molecular Weight: 289.699
• Mol file: 1352622-24-2.mol

Synonyms:4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile

Chemical Property of 4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile

There total 1 articles about 4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-amino-2-fluorobenzonitrile (53312-80-4) + 2,4-dichloro-6-cyclopropyl-<1,3,5>triazine (148312-23-6) → 4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile (1352622-24-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/ja2058583

Reference yield: 89.0%

4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile (1352622-24-2) → 4-((4-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile (1333950-40-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; triethylamine; In N,N-dimethyl-formamide; for 2h;

DOI:10.1021/ja2058583

Reference yield:

4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile (1352622-24-2) → C22H16N6O (1333950-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen; triethylamine / N,N-dimethyl-formamide / 2 h

2: potassium carbonate / dimethyl sulfoxide / 130 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ja2058583

upstream raw materials:

4-amino-2-fluorobenzonitrile

2,4-dichloro-6-cyclopropyl-<1,3,5>triazine

Downstream raw materials:

4-((4-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-fluorobenzonitrile

C₂₂H₁₆N₆O

C₂₂H₁₅ClN₆O

C₂₃H₁₈N₆O