(R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

Base Information

Chemical Name:(R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide
CAS No.:1205122-44-6
Molecular Formula:C₂₄H₂₈N₂O₅S
Molecular Weight:456.563
Hs Code.:

Synonyms:(R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

Chemical Property:

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Technology Process of (R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

There total 11 articles about (R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1205122-53-7
(R)-3-(4-benzyloxy-phenyl)-N-hydroxy-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

: 1205122-44-6
(R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 6h; under 2585.81 Torr;

Reference yield:

: 541-28-6
isopentyl iodide

: 1205122-44-6
(R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: hydrogenchloride; water / ethyl acetate

3: 4-methyl-morpholine; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

4: triethylsilane; trifluoroacetic acid / dichloromethane

With 4-methyl-morpholine; hydrogenchloride; triethylsilane; water; potassium carbonate; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.087

Reference yield:

: 93-11-8
2-Naphthalenesulfonyl chloride

: 1205122-44-6
(R)-N-hydroxy-3-(4-hydroxy-phenyl)-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: potassium carbonate / N,N-dimethyl-formamide

3: hydrogenchloride; water / ethyl acetate

4: 4-methyl-morpholine; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

5: triethylsilane; trifluoroacetic acid / dichloromethane

With 4-methyl-morpholine; hydrogenchloride; triethylsilane; water; potassium carbonate; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.087