3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

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Chemical Name:3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide
CAS No.:1607440-74-3
Molecular Formula:C₁₈H₁₈N₄O₂S
Molecular Weight:354.433
Hs Code.:

Synonyms:3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

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Chemical Property of 3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

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Technology Process of 3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

There total 8 articles about 3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1607441-31-5
3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxamide

: 1607440-74-3
3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: 3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxamide; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

With ammonium hydroxide; In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 31877-30-2
ethyl 4-phenyl-1,3-thiazole-2-carboxylate

: 1607440-74-3
3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -50 °C

2.1: ethanol / 15 h / 80 °C

3.1: hydrazine hydrate / ethanol / 0.25 h

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

4.2: 16 h / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

8.2: 1 h / 20 °C

With hydrazine hydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1607441-22-4
N-tert-butyl-3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxamide

: 1607440-74-3
3-(4-phenylthiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

2.2: 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;