N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide

Base Information

• Chemical Name: N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide
• CAS No.: 211503-92-3
• Molecular Formula: C₁₆H₂₂BrClN₂O₂
• Molecular Weight: 389.72
• Mol file: 211503-92-3.mol

Synonyms:N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide

Chemical Property of N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide

There total 38 articles about N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(-)-(1S,3R,4R)-4-(tert-butoxycarbonylamino)-3-(6-chloropyridin-3-yl)cyclohexyl methanesulphonate → N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide (211503-92-3)

Guidance literature:

With lithium bromide; In tetrahydrofuran; for 36h; Heating;

DOI:10.1021/ol016420q

Reference yield: 43.0%

C17H25ClN2O4S → N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide (211503-92-3)

Guidance literature:

With lithium bromide; In tetrahydrofuran; for 36h; Reflux;

DOI:10.1021/acs.joc.9b01340

Reference yield: 42.0%

(-)-tert-butyl N-[(1R,2R,4S)-2-(6-chloropyridin-3-yl)-4-hydroxycyclohexyl]carbamate (211503-91-2) → N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide (211503-92-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In acetonitrile; at 70 ℃; for 0.75h;

DOI:10.1021/jo9813078

upstream raw materials:

(-)-tert-butyl N-[(1R,2R,4S)-2-(6-chloropyridin-3-yl)-4-hydroxycyclohexyl]carbamate

3-[(2E)-3-(6-chloro(3-pyridyl))prop-2-enoyl](4R)-4-benzyl-1,3-oxazolidin-2-one

6-Chloro-3-pyridinecarboxylic acid

6-chloronicotinylaldehyde

Downstream raw materials:

(1R,2R,4R)-4-bromo-2-(6-chloropyridin-3-yl)cyclohexanamine

epibatidine