tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

Base Information

Chemical Name:tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate
CAS No.:1165797-54-5
Molecular Formula:C₂₆H₃₅N₃O₃
Molecular Weight:437.582
Hs Code.:

Synonyms:tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

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Chemical Property of tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

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Technology Process of tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

There total 2 articles about tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1165799-92-7
C₂₀H₃₀ClN₃O₃

: 98-80-6
phenylboronic acid

: 1165797-54-5
tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

Guidance literature:: With azetion-3-ol hydrochloride; palladium diacetate; In water; acetonitrile; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 25462-85-5
2-chloro-6-methylpyridine-4-carboxylic acid

: 166168-16-7
trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester

: 1165797-54-5
tert-butyl [(trans-4-{[(2-methyl-6-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

2: azetion-3-ol hydrochloride; palladium diacetate / water; acetonitrile / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With azetion-3-ol hydrochloride; palladium diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.014