(2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

Base Information

Chemical Name:(2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol
CAS No.:99545-28-5
Molecular Formula:C₂₀H₃₁NO₃S₂
Molecular Weight:397.603
Hs Code.:

Synonyms:(2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

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Chemical Property of (2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

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Technology Process of (2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

There total 5 articles about (2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 99545-26-3,99545-27-4
1-[2-(3,4-Dimethoxy-phenyl)-[1,3]dithian-2-yl]-2-hydroxy-oct-7-en-4-one O-benzyl-oxime

: 99545-28-5
(2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

Guidance literature:: With lithium aluminium tetrahydride; potassium methanolate; In tetrahydrofuran; -78 --> -15 deg C;
DOI:10.1246/cl.1985.1177

Reference yield:

: 50766-67-1
2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 99545-28-5
(2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / N-BuLi / tetrahydrofuran; hexane / 24 h / 0 °C

2: 76 percent / concd. HCl

3: 80 percent / 1.) lithium diisopropylamide / tetrahydrofuran / 1.) -78 deg C

4: pyridine; methanol / 5 h / Heating

5: 65 percent / LiAlH₄, potassium methoxide / tetrahydrofuran / 1.) -78 deg C, overnight; 2.) -78 to -15 deg C, 5 h; 3.) -15 deg C, 12 h

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; potassium methanolate; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; hexane;
DOI:10.1246/bcsj.59.525

Reference yield:

: 99545-23-0
2-formylmethyl-2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 99545-28-5
(2R,4R)-4-Amino-1-[2-(3,4-dimethoxy-phenyl)-[1,3]dithian-2-yl]-oct-7-en-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 1.) lithium diisopropylamide / tetrahydrofuran / 1.) -78 deg C

2: pyridine; methanol / 5 h / Heating

3: 65 percent / LiAlH₄, potassium methoxide / tetrahydrofuran / 1.) -78 deg C, overnight; 2.) -78 to -15 deg C, 5 h; 3.) -15 deg C, 12 h

With lithium aluminium tetrahydride; potassium methanolate; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol;
DOI:10.1246/bcsj.59.525