(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride

Base Information

• Chemical Name: (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride
• CAS No.: 204381-40-8
• Molecular Formula: C₃₂H₅₁ClO₃Si₂
• Molecular Weight: 575.379

Synonyms:(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride

Chemical Property of (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride

There total 7 articles about (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoic acid (204381-37-3) → (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride (204381-40-8)

Guidance literature:

With oxalyl dichloride; In hexane; N,N-dimethyl-formamide; for 0.75h; Ambient temperature;

DOI:10.1021/ja974010k

Reference yield:

methyl 4-formylbutanoate (6026-86-4) → (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride (204381-40-8)

Guidance literature:

Multi-step reaction with 7 steps

1: (-)-(1S,2R)-N,N-dibutylnorephedrine / hexane; toluene / 72 h / 0 °C

2: 84 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

3: 94 percent / DIBAL-H / CH₂Cl₂; toluene / 0.5 h / -78 °C

4: 1.) Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, from 0 to 5 deg C, 20 min, 2.) CH₂Cl₂, from -78 to 0 deg C, 3 h

5: 1.41 g / DMAP / CH₂Cl₂ / 144 h / Ambient temperature

6: 30percent aq. H₂O₂, LiOH / H₂O; tetrahydrofuran; dimethylformamide / 0 °C

7: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; lithium hydroxide; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; diisobutylaluminium hydride; (1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja974010k

Reference yield:

(S)-5-Hydroxy-heptanoic acid methyl ester (118545-01-0) → (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride (204381-40-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 84 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

2: 94 percent / DIBAL-H / CH₂Cl₂; toluene / 0.5 h / -78 °C

3: 1.) Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, from 0 to 5 deg C, 20 min, 2.) CH₂Cl₂, from -78 to 0 deg C, 3 h

4: 1.41 g / DMAP / CH₂Cl₂ / 144 h / Ambient temperature

5: 30percent aq. H₂O₂, LiOH / H₂O; tetrahydrofuran; dimethylformamide / 0 °C

6: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; lithium hydroxide; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja974010k

upstream raw materials:

(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoic acid

methyl 4-formylbutanoate

(S)-5-Hydroxy-heptanoic acid methyl ester

(S)-5-(tert-butyldimethylsiloxy)heptanal

Downstream raw materials:

2,2-Dimethyl-propionic acid (2R,3aS,5aR,6S,8aS,8bR)-7-[(2R,3S,7S)-7-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl]-6-[2-(4-methoxy-benzyloxy)-ethyl]-1,2,3,3a,5a,6,8a,8b-octahydro-as-indacen-2-yl ester

spinosyn A

(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-13-hydroxy-14-methyl-2-(((2R,3R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,3a,5b,6,9,10,11,12,13,14,16a,16b-dodecahydro-1H-as-indaceno[3,2-d][1]oxacyclododecine-7,15(2H,5aH)-dione

(2R,3S,3aR,5aS,7R,8aR,8bS)-2-[(2R,3S,7S)-3-(tert-butyldiphenylsiloxy)-7-hydroxy-2-methylnonanoyl]-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-7-hydroxy-as-indacene-3-acetic acid κ-lactone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 204381-40-8 (2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send