(1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester
CAS No.:1033756-01-2
Molecular Formula:C₁₄H₁₇ClFNO₂
Molecular Weight:285.746
Hs Code.:

Synonyms:(1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

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Chemical Property of (1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

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Technology Process of (1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

There total 1 articles about (1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 119993-55-4
(1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester hydrochloride

: 34328-61-5
3-Chloro-4-fluorobenzaldehyde

: 1033756-01-2
(1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

Guidance literature:: (1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester hydrochloride; 3-Chloro-4-fluorobenzaldehyde; In methanol; at 25 ℃; for 0.166667h;

With acetic acid; In methanol; at 25 ℃; for 0.0833333h;

With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; for 17h;

Reference yield:

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 1033756-01-2
(1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

: 1033756-02-3
(1R,2S)-2-{(3-chloro-4-fluoro-benzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-acetyl]-amino}-cyclopentanecarboxylic acid methyl ester

Guidance literature:: (7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid; (1R,2S)-2-(3-chloro-4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester; With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 0.0833333h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 15h;