4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester

Base Information

• Chemical Name: 4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester
• CAS No.: 84243-56-1
• Molecular Formula: C₁₃H₁₂N₂O₃
• Molecular Weight: 244.25
• Mol file: 84243-56-1.mol

Synonyms:4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester

Chemical Property of 4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester

There total 2 articles about 4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-(imidazol-1-yl)acetophenone (10041-06-2) + carbonic acid dimethyl ester (616-38-6) → 4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester (84243-56-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, RT, 1 h, 2.) THF, reflux, overnight;

DOI:10.1021/jm00148a006

Reference yield:

→ 4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester (84243-56-1)

Guidance literature:

Reference yield: 82.0%

4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester (84243-56-1) → 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-one (108818-74-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1021/jm00393a007

upstream raw materials:

4'-(imidazol-1-yl)acetophenone

carbonic acid dimethyl ester

Downstream raw materials:

2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-one

3-(4-Imidazol-1-yl-phenyl)-2-methyl-3-oxo-propionic acid methyl ester

4-(1H-imidazol-1-yl)-α,α-dimethyl-β-oxobenzenepropanoic acid methyl ester

2-(4-Imidazol-1-yl-benzoyl)-butyric acid methyl ester