benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate
CAS No.:1290056-57-3
Molecular Formula:C₂₈H₃₀N₂O₅
Molecular Weight:474.557
Hs Code.:

Synonyms:benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Suppliers and Price of benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

There total 6 articles about benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 102-32-9
3,4-dihydroxyphenylacetate

: 1290056-56-2
benzyl N-[[3-(4-piperidyl)phenyl]methyl]carbamate

: 1290056-57-3
benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 370864-42-9
4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1290056-57-3
benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium(II) hydroxide / ethanol / 2 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; tetrahydrofuran / 2 h / 0 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium(II) hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 6952-59-6
3-cyanobromobenzene

: 1290056-57-3
benzyl 3-(1-(2-(3,4-dihydroxyphenyl)acetyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -100 °C

1.2: 5 h / -100 - 20 °C

2.1: pyridine; trichlorophosphate / 72 h / 0 - 20 °C

3.1: hydrogen / palladium(II) hydroxide / ethanol / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 2 h / 0 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With pyridine; n-butyllithium; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; palladium(II) hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water;