(4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

Base Information

Chemical Name:(4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one
CAS No.:200186-30-7
Molecular Formula:C₁₇H₂₃IO₄
Molecular Weight:418.272
Hs Code.:

Synonyms:(4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

Chemical Property:

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Technology Process of (4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

There total 4 articles about (4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 200186-44-3
Carbonic acid (R)-5-benzyloxy-1-((R)-1-methyl-allyl)-pentyl ester tert-butyl ester

: 200186-30-7
(4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

Guidance literature:: With iodine(I) bromide; In dichloromethane; toluene; at -78 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tet.2009.04.001

Reference yield:

: 200186-44-3
Carbonic acid (R)-5-benzyloxy-1-((R)-1-methyl-allyl)-pentyl ester tert-butyl ester

: 200186-30-7
(4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

: (4R,5S,6S)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

Guidance literature:: With iodine(I) bromide; In toluene; at -78 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(97)10499-3

Reference yield:

: 78999-24-3
5-benzyloxy-1-pentanal

: 200186-30-7
(4R,5S,6R)-4-(4-Benzyloxy-butyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) BF₃*OEt₂; 2.) NaOH, H₂O₂ / 1.) -78 deg C

2: 89 percent / NaHMDS / tetrahydrofuran / 0 °C

3: IBr / toluene / -78 °C

With sodium hydroxide; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hexamethyldisilazane; iodine(I) bromide; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(97)10499-3