3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

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Chemical Name:3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine
CAS No.:1294002-24-6
Molecular Formula:C₂₁H₂₀F₃N₅O₃
Molecular Weight:447.417
Hs Code.:

Synonyms:3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

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Chemical Property of 3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

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Technology Process of 3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

There total 4 articles about 3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960491-87-6
(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidine

: 1294003-44-3
6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyrazine-2-carboxylic acid

: 1294002-24-6
3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1240469-32-2
5-bromo-3-methoxy-2-(4-methyl-1H-imidazol-1-yl)pyrazine

: 1294002-24-6
3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2.1: hydrogenchloride; water / 0.5 h / 60 °C

2.2: 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 476622-89-6
5-bromo-2-iodo-3-methoxypyrazine

: 1294002-24-6
3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-({(3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl}carbonyl)pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / trans-1,2-Diaminocyclohexane; copper(l) iodide / 1,4-dioxane / 0.5 h / Inert atmosphere; Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3.1: hydrogenchloride; water / 0.5 h / 60 °C

3.2: 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; potassium phosphate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-1,2-Diaminocyclohexane; In 1,4-dioxane; N,N-dimethyl-formamide;