methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

Base Information

Chemical Name:methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate
CAS No.:1069043-28-2
Molecular Formula:C₂₆H₂₄ClNO₂
Molecular Weight:417.935
Hs Code.:

Synonyms:methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

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Chemical Property of methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

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Technology Process of methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

There total 6 articles about methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 106-39-8
bromochlorobenzene

: 1069047-06-8
methyl 3-[3-(2-phenylethyl)-1H-indol-5-yl]propanoate

: 1069043-28-2
methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

Guidance literature:: With potassium phosphate; palladium diacetate; johnphos; In 1,2-dimethoxyethane; at 110 ℃; Sealed tube;
DOI:10.1021/jm500494y

Reference yield:

: 127876-36-2
2-(benzotriazol-1-yl)acetophenone

: 1069043-28-2
methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: titanium tetrachloride / dichloromethane / 3 h / 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C

3: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 5 h / 120 °C / Sealed tube

4: palladium on activated charcoal; hydrogen / methanol / 20 °C

5: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube

With potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; titanium tetrachloride; triethylamine; tris-(o-tolyl)phosphine; johnphos; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; toluene; 3: |Heck Reaction;
DOI:10.1021/jm500494y

Reference yield:

: 1069051-39-3
1-(5-bromo-1H-indol-3-yl)-2-phenylethanone

: 1069043-28-2
methyl 3-[1-(4-chlorophenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C

2: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 5 h / 120 °C / Sealed tube

3: palladium on activated charcoal; hydrogen / methanol / 20 °C

4: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube

With potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; johnphos; In methanol; 1,2-dimethoxyethane; diethyl ether; toluene; 2: |Heck Reaction;
DOI:10.1021/jm500494y