enalaprilate

Base Information

• Chemical Name: enalaprilate
• CAS No.: 84799-87-1
• Molecular Formula: C₁₈H₂₄N₂O₅
• Molecular Weight: 348.399
• Mol file: 84799-87-1.mol

Synonyms:enalaprilate

Chemical Property of enalaprilate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of enalaprilate

There total 4 articles about enalaprilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

alanylproline hydrochloride (87360-05-2) → enalaprilate (84799-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / H₂O / pH 7

2: 1) Na(CN)BH₃, 2) NaBH₄, aq. HCl / 1) H₂O, pH 7, 2 h, 2) H₂O, pH 7, room temperature, 10 d

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium cyanoborohydride; In water;

DOI:10.1007/BF01165900

Reference yield:

sodium salt of benzylidenepyruvic acid → enalaprilate (84799-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / H₂O / pH 7

2: 1) Na(CN)BH₃, 2) NaBH₄, aq. HCl / 1) H₂O, pH 7, 2 h, 2) H₂O, pH 7, room temperature, 10 d

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium cyanoborohydride; In water;

DOI:10.1007/BF01165900

Reference yield:

Sodium; (E)-2-[(Z)-(S)-2-((S)-2-carboxy-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylimino]-4-phenyl-but-3-enoate → enalaprilate (84799-87-1) + N-(1-carboxy-3-phenylpropen-2-yl)-(S,S)-alanylproline

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; sodium cyanoborohydride; Multistep reaction. Title compound not separated from byproducts; 1) H₂O, pH 7, 2 h, 2) H₂O, pH 7, room temperature, 10 d;

DOI:10.1007/BF01165900

upstream raw materials:

alanylproline hydrochloride