4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

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Chemical Name:4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide
CAS No.:872854-12-1
Molecular Formula:C₃₄H₄₀ClN₅O₅
Molecular Weight:634.175
Hs Code.:

4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

Synonyms:4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

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Chemical Property of 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

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Technology Process of 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

There total 5 articles about 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 872854-10-9
N-(5-amino-pentyl)-3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionamide

: 64987-85-5
4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester

: 872854-12-1
4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2005.07.015

Reference yield:

: 872854-00-7
[5-(12-aminopropionyl)amino-pentyl]-carbamic acid tert-butyl ester

: 872854-12-1
4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 4-methylmorpholine; phenol / 2 h / 100 °C

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

3: 78 percent / triethylamine / dimethylformamide / 20 °C

With 4-methyl-morpholine; triethylamine; trifluoroacetic acid; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2005.07.015

Reference yield:

: 872853-97-9
[5-(3-(allyloxycarbonyl)amino-propionyl)amino-pentyl]-carbamic acid tert-butyl ester

: 872854-12-1
4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propionylamino]-pentyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / diethylamine; tetrakis(triphenylphosphine)palladium / CH₂Cl₂ / 2 h / 20 °C

2: 79 percent / 4-methylmorpholine; phenol / 2 h / 100 °C

3: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

4: 78 percent / triethylamine / dimethylformamide / 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine; triethylamine; trifluoroacetic acid; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2005.07.015