(E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

Base Information

Chemical Name:(E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide
CAS No.:102437-91-2
Molecular Formula:C₂₄H₂₈N₂O₄S₂
Molecular Weight:472.629
Hs Code.:

Synonyms:(E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

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Chemical Property of (E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

There total 1 articles about (E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68563-71-3
trans-2-methyl-N-phenyl-1,3-oxathiolane-2-acetamide 3-oxide

: 102-01-2,98624-45-4
N-phenylacetoacetamide

: 102437-90-1
2-(5,6-Dihydro-[1,4]oxathiin-2-yl)-N-phenyl-acetamide

: 102437-91-2
(E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

: 5234-68-4
5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 96h; Yield given. Yields of byproduct given;
DOI:10.1021/jo00364a033

Reference yield:

: 102437-91-2
(E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

: 5234-68-4
5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 0.05 h / 0 °C

2: 1.) p-toluenesulfonic acid (PTSA), 2.) PTSA / 1.) C₆H₆, DMF, 50 deg C, 19 h, 2.) C₆H₆, reflux, 2.5 h

3: 90.2 percent / p-toluenesulfonic acid monohydrate (PTSA) / benzene / 5 h / Heating

4: 0.4968 g / 35percent aq. H₂O₂, acetic acid / 1 h / 15 - 20 °C

5: 1.) p-toluenesulfonic acid (PTSA), 2.) PTSA / 1.) C₆H₆, DMF, 50 deg C, 24 h, 2.) C₆H₆, reflux, 2.5 h

With dihydrogen peroxide; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; In chloroform; benzene;
DOI:10.1021/jo00364a033

Reference yield:

: 102437-91-2
(E)-3-{2-[2-((E)-1-Methyl-2-phenylcarbamoyl-vinyloxy)-ethyldisulfanyl]-ethoxy}-but-2-enoic acid phenylamide

: 102-01-2,98624-45-4
N-phenylacetoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 0.05 h / 0 °C

2: 1.) p-toluenesulfonic acid (PTSA), 2.) PTSA / 1.) C₆H₆, DMF, 50 deg C, 19 h, 2.) C₆H₆, reflux, 2.5 h

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In chloroform;
DOI:10.1021/jo00364a033