Technology Process of (7S,8R)-7-Benzyloxy-8-benzyloxymethyl-oxocan-2-one
There total 23 articles about (7S,8R)-7-Benzyloxy-8-benzyloxymethyl-oxocan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(6S,7R)-6,8-Bis-benzyloxy-7-hydroxy-octanoic acid;
With
2,4,6-trichlorobenzoyl chloride; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
With
dmap;
In
benzene;
for 4h;
Heating;
DOI:10.1016/S0040-4020(02)00045-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene / 80 °C
2.1: hydrogen / Pd(OH)2/C / ethyl acetate / 20 °C
2.2: TfOH / CH2Cl2 / 20 °C
2.3: 69 percent / aq. NaOH / tetrahydrofuran; methanol / 60 °C
3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C
3.2: 73 percent / 4-(dimethylamino)pyridine / tetrahydrofuran; benzene / 80 °C
With
2,4,6-trichlorobenzoyl chloride; hydrogen; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; ethyl acetate; toluene;
1.1: Wittig reaction;
DOI:10.1021/ol990885n
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 9-BBN / tetrahydrofuran / 20 °C
1.2: aq. NaHCO3; H2O2 / tetrahydrofuran / 0 °C
2.1: SO3*pyridine complex; triethylamine; DMSO / CH2Cl2 / 0 °C
3.1: toluene / 80 °C
4.1: hydrogen / Pd(OH)2/C / ethyl acetate / 20 °C
4.2: TfOH / CH2Cl2 / 20 °C
4.3: 69 percent / aq. NaOH / tetrahydrofuran; methanol / 60 °C
5.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C
5.2: 73 percent / 4-(dimethylamino)pyridine / tetrahydrofuran; benzene / 80 °C
With
9-borabicyclo[3.3.1]nonane dimer; pyridine-SO3 complex; 2,4,6-trichlorobenzoyl chloride; hydrogen; dimethyl sulfoxide; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
3.1: Wittig reaction;
DOI:10.1021/ol990885n
