1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea

Base Information

• Chemical Name: 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea
• CAS No.: 53672-80-3
• Molecular Formula: C₁₉H₂₅N₃O₅
• Molecular Weight: 375.425

Synonyms:1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea

Chemical Property of 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea

Chemical Property:

Purity/Quality:

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Technology Process of 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea

There total 3 articles about 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<2-(benzylamino)ethyl>-3-phenylurea (56443-68-6) → 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea (53672-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / 3 h / Heating

2: H₂, AcOH / 30percent Pd/C / 1.5 h

With hydrogen; acetic acid; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm00135a015

Reference yield:

4-(benzyloxy)-3-(hydroxymethyl)phenylglycidyl ether → 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea (53672-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / 3 h / Heating

2: H₂, AcOH / 30percent Pd/C / 1.5 h

With hydrogen; acetic acid; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm00135a015

Reference yield:

1-(2-{Benzyl-[3-(4-benzyloxy-3-hydroxymethyl-phenoxy)-2-hydroxy-propyl]-amino}-ethyl)-3-phenyl-urea → 1-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)-propylamino]-ethyl}-3-phenyl-urea (53672-80-3)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; for 1.5h;

DOI:10.1021/jm00135a015

upstream raw materials:

1-<2-(benzylamino)ethyl>-3-phenylurea

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