2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

Base Information

Chemical Name:2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide
CAS No.:1367125-43-6
Molecular Formula:C₂₁H₁₇FN₆O₂
Molecular Weight:404.403
Hs Code.:

Synonyms:2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

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Chemical Property of 2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

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Technology Process of 2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

There total 10 articles about 2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367127-19-2
C₂₂H₁₈FN₅O₃

: 1367125-43-6
2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 12h;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1367125-43-6
2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / 75 °C

6.1: ammonia / methanol / 12 h / 20 °C

7.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1 h / 0 °C

8.1: sodium azide; zinc dibromide / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation

9.1: sodium hexamethyldisilazane / tetrahydrofuran / 4 h / 20 °C

10.1: ammonia / methanol / 12 h / 20 °C

With sodium azide; sulfuric acid; tetrabutyl ammonium fluoride; ammonia; hydrogen; sodium hexamethyldisilazane; potassium carbonate; triethylamine; trifluoroacetic anhydride; zinc dibromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1367125-43-6
2-(5-(2-(4-(4-fluorophenoxy)phenyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / 75 °C

6.1: ammonia / methanol / 12 h / 20 °C

7.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1 h / 0 °C

8.1: sodium azide; zinc dibromide / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation

9.1: sodium hexamethyldisilazane / tetrahydrofuran / 4 h / 20 °C

10.1: ammonia / methanol / 12 h / 20 °C

With sodium azide; sulfuric acid; tetrabutyl ammonium fluoride; ammonia; hydrogen; sodium hexamethyldisilazane; potassium carbonate; triethylamine; trifluoroacetic anhydride; zinc dibromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;