benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Base Information

Chemical Name:benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate
CAS No.:1450620-71-9
Molecular Formula:C₂₇H₂₉F₃N₂O₄
Molecular Weight:502.533
Hs Code.:

Synonyms:benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

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Chemical Property of benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

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Technology Process of benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

There total 8 articles about benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 1450620-70-8
4-(4-bromophenyl)-2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolane

: 1450620-71-9
benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Guidance literature:: With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 136476-20-5
1-bromo-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1450620-71-9
benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / 6 h / 20 °C

2: toluene-4-sulfonic acid / 40 h / 20 °C

3: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With osmium(VIII) oxide; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; sodium t-butanolate; ruphos; In 1,4-dioxane;

Reference yield:

: 1361218-24-7
2-(4-bromophenyl)-3,3,3-trifluoro-1,2-propanediol

: 1450620-71-9
benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 40 h / 20 °C

2: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; toluene-4-sulfonic acid; sodium t-butanolate; ruphos; In 1,4-dioxane;