N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

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Chemical Name:N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide
CAS No.:1324003-50-0
Molecular Formula:C₂₁H₂₂ClN₃O₂
Molecular Weight:383.878
Hs Code.:

Synonyms:N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

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Chemical Property of N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

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Technology Process of N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

There total 4 articles about N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1324003-53-3
4-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)benzamide

: 1324003-50-0
N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

Guidance literature:: 4-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)benzamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1324003-17-9
6-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridine

: 1324003-50-0
N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / palladium diacetate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl / 1,4-dioxane; tert-butyl alcohol / 140 °C / Inert atmosphere

2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 60 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

With potassium phosphate; N-chloro-succinimide; tetrabutyl ammonium fluoride; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 74976-31-1
6-chloro-1H-pyrrolo[3,2-c]pyridine

: 1324003-50-0
N-(3-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / [2,2]bipyridinyl; copper diacetate / 1,2-dichloro-ethane / 70 °C

2: potassium phosphate / palladium diacetate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl / 1,4-dioxane; tert-butyl alcohol / 140 °C / Inert atmosphere

3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 60 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

With potassium phosphate; N-chloro-succinimide; tetrabutyl ammonium fluoride; sodium carbonate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; [2,2]bipyridinyl; copper diacetate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;