C₄₄H₅₃N₆O₁₄P

Base Information

• Chemical Name: C₄₄H₅₃N₆O₁₄P
• CAS No.: 1608113-31-0
• Molecular Formula: C₄₄H₅₃N₆O₁₄P
• Molecular Weight: 920.91
• Mol file: 1608113-31-0.mol

Synonyms:C₄₄H₅₃N₆O₁₄P

Chemical Property of C₄₄H₅₃N₆O₁₄P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₅₃N₆O₁₄P

There total 18 articles about C₄₄H₅₃N₆O₁₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C30H40N6O11 (1608113-30-9) + Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) → C44H53N6O14P (1608113-31-0)

Guidance literature:

C₃₀H₄₀N₆O₁₁; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 12h; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; acetonitrile; at -40 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201301781

Reference yield: 78.0%

N-For-Gly-L-Lys(NH2*TFA)-L-Phe-OMe (1608114-14-2) + C31H30N3O12P (1608113-35-4) → C44H53N6O14P (1608113-31-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201301781

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C44H53N6O14P (1608113-31-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine; dmap / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

4.1: acetic acid / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

5.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

5.2: 2 h / -40 - 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; dmap; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201301781

upstream raw materials:

thymidine

Dibenzyl N,N-diisopropylphosphoramidite

C₃₀H₄₀N₆O₁₁

N-For-Gly-L-Lys(Boc)-L-Phe-OMe