(S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester

Base Information

• Chemical Name: (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester
• CAS No.: 187876-74-0
• Molecular Formula: C₁₄H₁₈ClIN₂O₃
• Molecular Weight: 424.666

Synonyms:(S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester

Chemical Property of (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester

Chemical Property:

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Technology Process of (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester

There total 3 articles about (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-3-(5-Iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester (187876-40-0) → (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester (187876-74-0)

Guidance literature:

With chlorine; acetic acid; for 2h; Ambient temperature;

DOI:10.1021/jm960652r

Reference yield:

5-iodo-N-methylisatoic anhydride (151979-22-5) → (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester (187876-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / Et₃N, (dimethylamino)pyridine / CH₂Cl₂ / 13 h / Ambient temperature

2: 93 percent / Cl₂(g), AcOH / 2 h / Ambient temperature

With dmap; chlorine; acetic acid; triethylamine; In dichloromethane;

DOI:10.1021/jm960652r

Reference yield:

[(1S)-3-ethoxy-1-methyl-3-oxopropyl]ammonium chloride (146293-15-4,102014-64-2) → (S)-3-(3-Chloro-5-iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester (187876-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / Et₃N, (dimethylamino)pyridine / CH₂Cl₂ / 13 h / Ambient temperature

2: 93 percent / Cl₂(g), AcOH / 2 h / Ambient temperature

With dmap; chlorine; acetic acid; triethylamine; In dichloromethane;

DOI:10.1021/jm960652r

upstream raw materials:

(S)-3-(5-Iodo-2-methylamino-benzoylamino)-butyric acid ethyl ester

5-iodo-N-methylisatoic anhydride

[(1S)-3-ethoxy-1-methyl-3-oxopropyl]ammonium chloride

Downstream raw materials:

(S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-9-chloro-1-methyl-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-butyric acid ethyl ester

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