N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

Base Information

Chemical Name:N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride
CAS No.:886842-78-0
Molecular Formula:C₁₀H₁₆N₂O₂S*ClH
Molecular Weight:264.776
Hs Code.:

Synonyms:N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

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Chemical Property of N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

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Technology Process of N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

There total 5 articles about N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 886842-77-9
N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide

: 886842-78-0
N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 18 - 25 ℃; for 0.5h;

Reference yield:

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

: 886842-78-0
N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 0.17 h / 120 °C / Microwave irradiation

3.1: tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

4.1: sodium tetrahydroborate / tetrahydrofuran / 5 h / -70 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; caesium carbonate; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 252561-07-2
4-acetyl-2-methylphenyl trifluoromethanesulfonate

: 886842-78-0
N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 0.17 h / 120 °C / Microwave irradiation

2.1: tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran / 5 h / -70 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; methanol;