(E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate

Base Information

• Chemical Name: (E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate
• CAS No.: 1414031-96-1
• Molecular Formula: C₂₁H₂₀O₅
• Molecular Weight: 352.387
• Mol file: 1414031-96-1.mol

Synonyms:(E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate

Chemical Property of (E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate

There total 1 articles about (E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate + trans-4-fluorocinnamaldehyde (24654-55-5,51791-26-5,213617-57-3) → (E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate (1414031-96-1)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 120 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.09.010

Reference yield: 95.0%

(E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate (1414031-96-1) → ethyl 3-(3-(4-(3-hydroxypropyl)phenoxy)-4-methoxyphenyl)propanoate (1414032-00-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2012.09.010

Reference yield:

(E)-ethyl 3-(4-methoxy-3-(4-((E)-3-oxoprop-1-en-1-yl)phenoxy)phenyl)acrylate (1414031-96-1) → 3-(3-(4-(3-hydroxypropyl)phenoxy)-4-methoxyphenyl) propanoic acid (1414032-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; water; methanol / 3 h / 0 °C / Inert atmosphere

2.2: pH Ca_. 2

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate;

DOI:10.1016/j.tetlet.2012.09.010

upstream raw materials:

trans-4-fluorocinnamaldehyde

Downstream raw materials:

ethyl 3-(3-(4-(3-hydroxypropyl)phenoxy)-4-methoxyphenyl)propanoate

3-(3-(4-(3-hydroxypropyl)phenoxy)-4-methoxyphenyl) propanoic acid