2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

Base Information

Chemical Name:2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one
CAS No.:1297599-56-4
Molecular Formula:C₃₀H₂₅F₄N₅O
Molecular Weight:547.555
Hs Code.:

Synonyms:2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

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Chemical Property of 2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

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Technology Process of 2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

There total 7 articles about 2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460-37-7,71215-70-8
1,1,1-trifluoro-3-iodopropane

: 1297599-78-0
2-amino-4-(4-fluoro-phenyl)-9-(4-piperazin-1-yl-phenyl)-indeno[1,2-d]pyrimidin-5-one

: 1297599-56-4
2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 16h;

Reference yield:

: 1297599-74-6
4-(4-Fluoro-phenyl)-9-methoxy-5H-indeno[1,2-d]pyrimidin-2-ylamine

: 1297599-56-4
2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; oxygen / 1-methyl-pyrrolidin-2-one / 16 h / 80 °C

2.1: water; lithium chloride / 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Microwave irradiation

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h

3.2: 3 h

4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 85 °C

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 16 h / 70 °C

With potassium tert-butylate; water; oxygen; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

Reference yield:

: 1297599-73-5
2-(4-fluoro-benzylidene)-7-methoxy-indan-1-one

: 1297599-56-4
2-Amino-4-(4-fluoro-phenyl)-9-{4-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-phenyl}-indeno[1,2-d]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol / 0.5 h

1.2: Reflux

2.1: sodium hydroxide; oxygen / 1-methyl-pyrrolidin-2-one / 16 h / 80 °C

3.1: water; lithium chloride / 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Microwave irradiation

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h

4.2: 3 h

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 85 °C

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 16 h / 70 °C

With potassium tert-butylate; water; oxygen; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;