{1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

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Chemical Name:{1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester
CAS No.:609347-74-2
Molecular Formula:C₂₈H₄₀N₂O₄Si
Molecular Weight:496.722
Hs Code.:

Synonyms:{1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

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Chemical Property of {1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

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Technology Process of {1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

There total 6 articles about {1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(dimethyl-phenyl-silanyl)-5-methoxymethyl-pyrrolidine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 609347-74-2
{1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ja064737l

Reference yield:

: 916049-16-6
2-methoxymethylpyrrolidine-1-carboxylic acid tert-butyl ester

: 609347-74-2
{1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / tetraethylammonium tosylate / Electrolysis

2.1: lithium / tetrahydrofuran / 12 h / 20 °C

2.2: copper cyanide / tetrahydrofuran; diethyl ether / 0.17 h / 20 °C

2.3: 61 percent / BF₃*OEt₂ / tetrahydrofuran; diethyl ether / 3 h / -40 °C

3.1: aq. HCl / ethyl acetate / 0.5 h / 20 °C

4.1: 1.26 g / triethylamine; DCC; HOBt / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; lithium; tetraethylammonium tosylate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja064737l

Reference yield:

: 916049-17-7
2-methoxy-5-methoxymethylpyrrolidine-1-carboxylic acid tert-butyl ester

: 609347-74-2
{1-benzyl-2-[2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidin-1-yl]-2-oxoethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium / tetrahydrofuran / 12 h / 20 °C

1.2: copper cyanide / tetrahydrofuran; diethyl ether / 0.17 h / 20 °C

1.3: 61 percent / BF₃*OEt₂ / tetrahydrofuran; diethyl ether / 3 h / -40 °C

2.1: aq. HCl / ethyl acetate / 0.5 h / 20 °C

3.1: 1.26 g / triethylamine; DCC; HOBt / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; lithium; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja064737l