(+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

Base Information

Chemical Name:(+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one
CAS No.:128631-56-1
Molecular Formula:C₁₈H₂₂N₄O₃
Molecular Weight:342.398
Hs Code.:

Synonyms:(+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

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Chemical Property of (+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

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Technology Process of (+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

There total 8 articles about (+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

: 128631-55-0
(+/-)-1-(2-amino-4-chloro-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-(benzyloxy)pentan-3-ol

: 128631-56-1
(+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

Guidance literature:: With hydrogenchloride; In ethanol; for 18h; Heating;
DOI:10.1021/jm00171a022

Reference yield:

: 70388-33-9
4-benzyloxybut-1-ene

: 128631-56-1
(+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 95 percent / Et₂AlCl / hexane / Ambient temperature

3: 58 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

4: 8.35 g / Et₃N / butan-1-ol / 72 h / 100 °C

5: 75 percent / 0.25 N aq. HCl / ethanol / 72 h / Ambient temperature

6: 80.4 percent / 1 N aq. HCl / ethanol / 18 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; diethylaluminium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; hexane; dichloromethane; butan-1-ol;
DOI:10.1021/jm00171a022

Reference yield:

: 128631-53-8
(+/-)-1-amino-5-(benzyloxy)pentan-3-ol

: 128631-56-1
(+/-)-2-amino-7-<5-(benzyloxy)-3-hydroxypent-1-yl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 8.35 g / Et₃N / butan-1-ol / 72 h / 100 °C

2: 75 percent / 0.25 N aq. HCl / ethanol / 72 h / Ambient temperature

3: 80.4 percent / 1 N aq. HCl / ethanol / 18 h / Heating

With hydrogenchloride; triethylamine; In ethanol; butan-1-ol;
DOI:10.1021/jm00171a022