3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide

Base Information

• Chemical Name: 3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide
• CAS No.: 151669-41-9
• Molecular Formula: C₂₄H₂₆BrO₁₁P
• Molecular Weight: 601.342
• Mol file: 151669-41-9.mol

Synonyms:3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide

Chemical Property of 3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide

There total 2 articles about 3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3,4,6-Tetra-O-acetyl-2-O-(diphenoxyphosphoryl)-β-D-mannopyranose (151669-40-8) → 3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide (151669-41-9)

Guidance literature:

With hydrogen bromide; In dichloromethane; acetic acid; for 16h; ice cooling to room temperature;

DOI:10.1002/hlca.19930760426

Reference yield:

1,3,4,6-tetra-O-acetyl-β-D-mannopyranose (18968-05-3) → 3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide (151669-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 1-methyl-1H-imidazole / CH₂Cl₂ / 16 h / ice cooling to room temperature

2: 95 percent / HBr / CH₂Cl₂; acetic acid / 16 h / ice cooling to room temperature

With 1-methyl-1H-imidazole; hydrogen bromide; In dichloromethane; acetic acid;

DOI:10.1002/hlca.19930760426

Reference yield: 77.0%

3,4,6-Tri-O-acetyl-2-O-(diphenoxyphosphoryl)-α-D-mannopyranosyl bromide (151669-41-9) → 3,4,6-Tri-O-acetyl-1,5-anhydro-2-O-(diphenoxyphosphoryl)-D-mannitol

Guidance literature:

With tri-n-butyl-tin hydride; In diethyl ether; at 20 ℃; for 0.75h; Irradiation;

DOI:10.1002/hlca.19930760426

upstream raw materials:

1,3,4,6-Tetra-O-acetyl-2-O-(diphenoxyphosphoryl)-β-D-mannopyranose

1,3,4,6-tetra-O-acetyl-β-D-mannopyranose