3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

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Chemical Name:3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline
CAS No.:1443238-06-9
Molecular Formula:C₂₁H₂₅N₅O₂Si
Molecular Weight:407.547
Hs Code.:

Synonyms:3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

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Chemical Property of 3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

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Technology Process of 3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

There total 9 articles about 3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443238-05-8
5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)oxazole

: 1443238-06-9
3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

Guidance literature:: With hydrogen; In methanol; at 25 ℃; for 3h; under 760.051 Torr;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1443238-06-9
3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C / Inert atmosphere

1.2: 14.5 h / -78 - 30 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 1.5 h / 115 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

3.2: 4 h / 15 - 25 °C / Inert atmosphere

4.1: lithium hydroxide / methanol / 17 h / 60 °C / Inert atmosphere

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

7.1: potassium hydroxide / methanol / 12 h / 15 - 25 °C / Inert atmosphere

8.1: hydrogen; / methanol / 3 h / 25 °C / 760.05 Torr

With lithium aluminium tetrahydride; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1443237-43-1
ethyl 4-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

: 1443238-06-9
3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

1.2: 4 h / 15 - 25 °C / Inert atmosphere

2.1: lithium hydroxide / methanol / 17 h / 60 °C / Inert atmosphere

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

5.1: potassium hydroxide / methanol / 12 h / 15 - 25 °C / Inert atmosphere

6.1: hydrogen; / methanol / 3 h / 25 °C / 760.05 Torr

With lithium aluminium tetrahydride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;