2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

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Chemical Name:2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide
CAS No.:1413914-29-0
Molecular Formula:C₂₃H₂₄N₆O₂
Molecular Weight:416.483
Hs Code.:

Synonyms:2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

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Chemical Property of 2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

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Technology Process of 2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

There total 7 articles about 2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413914-32-5
2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

: 1413914-29-0
2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

Guidance literature:: 2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; pH=7 - 8;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413914-29-0
2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

4.2: 4 h / 110 °C

5.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

6.1: piperidine / methanol / 5 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

7.2: pH 7 - 8

With piperidine; diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; caesium carbonate; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin oil;

Reference yield:

: 1184852-23-0
1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

: 1413914-29-0
2-cyano-3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-N-ethyl-prop-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

2.2: 4 h / 110 °C

3.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

4.1: piperidine / methanol / 5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.2: pH 7 - 8

With piperidine; sodium hydride; caesium carbonate; pyridinium chlorochromate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin oil;